![]() ![]() The BiRDS fuses miR inhibitors within the framework, maximizing their loading capacity, while allowing the system to retain the characteristics of small-sized tFNA and avoiding uncertainty associated with RNA exposure in traditional loading protocols. Inspired by the ancient Chinese myth “Sun and Immortal Birds,” a novel bioswitchable miR inhibitor delivery system (BiRDS) is designed with three miR inhibitors (the three immortal birds) and a nucleic acid core (the central sun). Tetrahedral framework DNA (tFNA) has proven to be an ideal vehicle for miR therapy. MicroRNA (miR)-based therapy shows strong potential however, structural limitations pose a challenge in fully exploiting its biomedical functionality.
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